| Gene Information | |
|---|---|
| Gene Name | SMAD9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000120693 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15198 |
| Gene Card | SMAD9 |
| Uniprot ID | O15198 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | no (-0.11610881) |
| Ortholog in Animals | Alpaca_ SMAD9 ( ortholog_one2one ) Dog_ SMAD9 ( ortholog_one2one ) Macaque_ SMAD9 ( ortholog_one2one ) Pig_ SMAD9 ( ortholog_one2one ) Rabbit_ SMAD9 ( ortholog_one2one ) |
| Ohnologs | SMAD3, SMAD2, SMAD5, SMAD1 |
| Paralogs | SMAD6, SMAD2, SMAD3, SMAD5, SMAD4, SMAD7, SMAD1 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6FZT (X-ray 2.46A ) |
| DBSNP | rs397514715 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}. |
| Mouse PG classification | HPG |
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