| Gene Information | |
|---|---|
| Gene Name | LGR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 907 |
| Protein Names | Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) |
| Target Name | leucine-rich repeat-containing gpcr 5 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000139292 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75473 |
| Gene Card | LGR5 |
| Uniprot ID | O75473 |
| Pfam | PF00560; PF13855; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.553513472) |
| Ortholog in Animals | Alpaca_ LGR5 ( ortholog_one2one ) Dog_ LGR5 ( ortholog_one2one ) GuineaPig_ LGR5 ( ortholog_one2one ) Macaque_ LGR5 ( ortholog_one2one ) Mouse_ Lgr5 ( ortholog_one2one ) Pig_ LGR5 ( ortholog_one2one ) Rat_ Lgr5 ( ortholog_one2one ) Rabbit_ LGR5 ( ortholog_one2one ) |
| Ohnologs | LGR6, LGR4 |
| Paralogs | LRG1, CPN2, LRRTM2, LRRC52, LRIT3, LRRC24, ELFN2, LRIG3, LGR6, CHAD, CHADL, LRIT1, TRIL, ELFN1, LGR4, LGI2, LGI1, LRIG2, LRRC26, LRIG1, LGI3, LGI4 |
| Tissue | placenta |
| Tissue Specificity | Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269|PubMed:12601349, ECO:0000269|PubMed:16575208, ECO:0000269|PubMed:19030762}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4BSR (X-ray 3.20A ) 4BSS (X-ray 3.20A ) 4BST (X-ray 4.30A ) 4BSU (X-ray 3.20A ) 4KNG (X-ray 2.50A ) 4UFR (X-ray 2.20A ) 4UFS (X-ray 4.80A ) |
| DBSNP | rs12303775 rs17109924 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}. |
| Mouse PG classification | NA |
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