| Gene Information | |
|---|---|
| Gene Name | SMAD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137834 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43541 |
| Gene Card | SMAD6 |
| Uniprot ID | O43541 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | no (-0.337581371) |
| Ortholog in Animals | Alpaca_ SMAD6 ( ortholog_one2one ) Dog_ SMAD6 ( ortholog_one2one ) GuineaPig_ SMAD6 ( ortholog_one2one ) Macaque_ SMAD6 ( ortholog_one2one ) Mouse_ Smad6 ( ortholog_one2one ) Pig_ SMAD6 ( ortholog_one2one ) Rat_ Smad6 ( ortholog_one2one ) |
| Ohnologs | SMAD7 |
| Paralogs | SMAD2, SMAD3, SMAD5, SMAD4, SMAD7, SMAD1, SMAD9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.013613(Mouse);0.001704(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1359442505 rs768542939 rs1595757271 rs1395007983 rs1419095990 rs1396117157 rs570279865 rs1374099442 rs199822239 rs900988907 rs142278375 rs1567115899 rs387907284 rs761888345 rs1595805424 rs387907283 rs1338294058 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16491121}. |
| Mouse PG classification | HPG |
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