Gene Information | |
---|---|
Gene Name | SMAD4 |
Organism | Homo sapiens (Human) |
Gene Length | 552 |
Protein Names | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) |
Target Name | NA |
Target Type | NA |
Gene Age | 987 ( ENSG00000141646 ) |
Evolutionary Stage | Eumetazoa |
AlphaFoldDB | Q13485 |
Gene Card | SMAD4 |
Uniprot ID | Q13485 |
Pfam | PF03165; PF03166 |
In ASD | no |
Allosteric Prediction | yes (0.533597652) |
Ortholog in Animals | Alpaca_ SMAD4 ( ortholog_one2one ) Dog_ SMAD4 ( ortholog_one2one ) GuineaPig_ SMAD4 ( ortholog_one2one ) Macaque_ SMAD4 ( ortholog_one2one ) Mouse_ Smad4 ( ortholog_one2one ) Pig_ SMAD4 ( ortholog_one2one ) Rat_ Smad4 ( ortholog_one2one ) Rabbit_ SMAD4 ( ortholog_one2one ) |
Ohnologs | NA |
Paralogs | SMAD6, SMAD2, SMAD3, SMAD5, SMAD7, SMAD1, SMAD9 |
Tissue | NA |
Tissue Specificity | NA |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035088(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1DD1 (X-ray 2.62A ) 1G88 (X-ray 3.00A ) 1MR1 (X-ray 2.85A ) 1U7F (X-ray 2.60A ) 1U7V (X-ray 2.70A ) 1YGS (X-ray 2.10A ) 5C4V (X-ray 2.60A ) 5MEY (X-ray 2.05A ) 5MEZ (X-ray 2.98A ) 5MF0 (X-ray 3.03A ) 5UWU (X-ray 2.24A ) 6YIC (X-ray 1.60A ) |
DBSNP | rs281875323 rs1555685186 rs281875324 rs1057519739 rs121912581 rs80338963 rs377767347 rs121912580 rs121912578 rs281875320 rs281875321 rs281875322 |
Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. Nucleus {ECO:0000269|PubMed:15799969}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. |
Mouse PG classification | LPG |
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