Gene Information
Gene NameSMAD4
OrganismHomo sapiens (Human)
Gene Length552
Protein NamesMothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000141646 )
Evolutionary StageEumetazoa
AlphaFoldDBQ13485
Gene CardSMAD4
Uniprot IDQ13485
PfamPF03165; PF03166
In ASDno
Allosteric Predictionyes (0.533597652)
Ortholog in AnimalsAlpaca_ SMAD4 ( ortholog_one2one )
Dog_ SMAD4 ( ortholog_one2one )
GuineaPig_ SMAD4 ( ortholog_one2one )
Macaque_ SMAD4 ( ortholog_one2one )
Mouse_ Smad4 ( ortholog_one2one )
Pig_ SMAD4 ( ortholog_one2one )
Rat_ Smad4 ( ortholog_one2one )
Rabbit_ SMAD4 ( ortholog_one2one )
OhnologsNA
ParalogsSMAD6, SMAD2, SMAD3, SMAD5, SMAD7, SMAD1, SMAD9
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035088(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1DD1  (X-ray  2.62A  1G88  (X-ray  3.00A  1MR1  (X-ray  2.85A  1U7F  (X-ray  2.60A  1U7V  (X-ray  2.70A  1YGS  (X-ray  2.10A  5C4V  (X-ray  2.60A  5MEY  (X-ray  2.05A  5MEZ  (X-ray  2.98A  5MF0  (X-ray  3.03A  5UWU  (X-ray  2.24A  6YIC  (X-ray  1.60A 
DBSNP rs281875323  rs1555685186  rs281875324  rs1057519739  rs121912581  rs80338963  rs377767347  rs121912580  rs121912578  rs281875320  rs281875321  rs281875322 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. Nucleus {ECO:0000269|PubMed:15799969}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}.
Mouse PG classificationLPG
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