| Gene Information | |
|---|---|
| Gene Name | SMAD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000170365 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15797 |
| Gene Card | SMAD1 |
| Uniprot ID | Q15797 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | yes (0.163917542) |
| Ortholog in Animals | Alpaca_ SMAD1 ( ortholog_one2one ) Dog_ SMAD1 ( ortholog_one2one ) GuineaPig_ SMAD1 ( ortholog_one2one ) Macaque_ SMAD1 ( ortholog_one2one ) Mouse_ Smad1 ( ortholog_one2one ) Pig_ SMAD1 ( ortholog_one2one ) Rat_ Smad1 ( ortholog_one2one ) Rabbit_ SMAD1 ( ortholog_one2one ) |
| Ohnologs | SMAD5, SMAD9, SMAD3 |
| Paralogs | SMAD6, SMAD2, SMAD3, SMAD5, SMAD4, SMAD7, SMAD9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highest expression seen in the heart and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001801(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1KHU (X-ray 2.50A ) 2LAW (NMR - ) 2LAX (NMR - ) 2LAY (NMR - ) 2LAZ (NMR - ) 2LB0 (NMR - ) 2LB1 (NMR - ) 3Q47 (X-ray 1.70A ) 3Q4A (X-ray 1.54A ) 5ZOK (X-ray 2.85A ) |
| DBSNP | rs587777018 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15647271}. Nucleus {ECO:0000269|PubMed:15647271, ECO:0000269|PubMed:22781750}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:15647271}. |
| Mouse PG classification | NA |
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