| Gene Information | |
|---|---|
| Gene Name | SMAC |
| Organism | Homo sapiens (Human) |
| Gene Length | 239 |
| Protein Names | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NR28 |
| Gene Card | DIABLO |
| Uniprot ID | Q9NR28 |
| Pfam | PF09057 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FEW (X-ray 2.20A ) 1G3F (NMR - ) 1G73 (X-ray 2.00A ) 1OXQ (X-ray 2.30A ) 1TW6 (X-ray 1.71A ) 1XB0 (X-ray 2.20A ) 1XB1 (X-ray 2.70A ) 3D9U (X-ray 2.30A ) 3UIH (X-ray 2.40A ) 3UIJ (X-ray 2.70A ) 4TX5 (X-ray 1.80A ) 6JX6 (X-ray 2.81A ) |
| DBSNP | rs387906893 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:14523016}. Note=Released into the cytosol when cells undergo apoptosis. |
| Mouse PG classification | NA |
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