| Gene Information | |
|---|---|
| Gene Name | PRKAR2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | cAMP-dependent protein kinase type II-alpha regulatory subunit |
| Target Name | camp-dependent protein kinase type ii-alpha regulatory subunit |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000114302 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P13861 |
| Gene Card | PRKAR2A |
| Uniprot ID | P13861 |
| Pfam | PF00027; PF02197 |
| In ASD | no |
| Allosteric Prediction | yes (0.894499215) |
| Ortholog in Animals | Alpaca_ PRKAR2A ( ortholog_one2one ) Dog_ PRKAR2A ( ortholog_one2one ) GuineaPig_ PRKAR2A ( ortholog_one2one ) Macaque_ PRKAR2A ( ortholog_one2one ) Mouse_ Prkar2a ( ortholog_one2one ) Pig_ PRKAR2A ( ortholog_one2one ) Rat_ Prkar2a ( ortholog_one2one ) Rabbit_ PRKAR2A ( ortholog_one2one ) |
| Ohnologs | PRKAR2B |
| Paralogs | CNBD1, PRKAR2B, PRKAR1A, PRKAR1B |
| Tissue | NA |
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016216(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IZX (X-ray 1.30A ) 2KYG (NMR - ) 4ZP3 (X-ray 2.63A ) 5H78 (X-ray 2.00A ) 5XBY (X-ray 3.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane. |
| Mouse PG classification | NA |
| click here to return to the previous page | |