| Gene Information | |
|---|---|
| Gene Name | MAST2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1798 |
| Protein Names | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000086015 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6P0Q8 |
| Gene Card | MAST2 |
| Uniprot ID | Q6P0Q8 |
| Pfam | PF08926; PF17820; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.482682642) |
| Ortholog in Animals | Alpaca_ MAST2 ( ortholog_one2one ) Dog_ MAST2 ( ortholog_one2one ) GuineaPig_ MAST2 ( ortholog_one2one ) Macaque_ MAST2 ( ortholog_one2one ) Mouse_ Mast2 ( ortholog_one2one ) Pig_ MAST2 ( ortholog_one2one ) Rat_ Mast2 ( ortholog_one2one ) |
| Ohnologs | MAST4, MAST3, MAST1 |
| Paralogs | STK32B, MAST3, STK32A, LATS2, SGK1, MAST4, SGK2, SGK3, LATS1, STK32C, MAST1, DMPK, MASTL |
| Tissue | NA |
| Tissue Specificity | Abundant in the testis. {ECO:0000269|PubMed:8902215}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KQF (NMR - ) 2KYL (NMR - ) |
| DBSNP | rs55914403 rs11211247 rs1707336 rs56114653 rs1052607 rs56060730 rs56309943 rs33931638 rs3737738 rs3737737 rs1052610 rs35474583 rs34070850 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12117771}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the sub-membranous area on interaction with CDHR2. |
| Mouse PG classification | NA |
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