| Gene Information | |
|---|---|
| Gene Name | SLC7A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 535 |
| Protein Names | Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) |
| Target Name | large neutral amino acids transporter small subunit 2 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000092068 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UHI5 |
| Gene Card | SLC7A8 |
| Uniprot ID | Q9UHI5 |
| Pfam | PF13520 |
| In ASD | no |
| Allosteric Prediction | no (-0.423502517) |
| Ortholog in Animals | Alpaca_ SLC7A8 ( ortholog_one2one ) Dog_ SLC7A8 ( ortholog_one2one ) GuineaPig_ SLC7A8 ( ortholog_one2one ) Macaque_ SLC7A8 ( ortholog_one2one ) Mouse_ Slc7a8 ( ortholog_one2one ) Pig_ SLC7A8 ( ortholog_one2one ) Rat_ Slc7a8 ( ortholog_one2one ) Rabbit_ SLC7A8 ( ortholog_one2one ) |
| Ohnologs | SLC7A6, SLC7A5, SLC7A10 |
| Paralogs | SLC7A6, SLC7A10, SLC7A9, SLC7A11, SLC7A13, SLC7A14, SLC7A7, SLC7A3, SLC7A2, SLC7A4, SLC7A1, SLC7A5 |
| Tissue | NA |
| Tissue Specificity | Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2. {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:16027961}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7B00 (EM 3.98A ) 7CMH (EM 3.40A ) 7CMI (EM 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. |
| Mouse PG classification | NA |
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