| Gene Information | |
|---|---|
| Gene Name | LZTS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 596 |
| Protein Names | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000061337 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y250 |
| Gene Card | LZTS1 |
| Uniprot ID | Q9Y250 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.678532698) |
| Ortholog in Animals | Alpaca_ LZTS1 ( ortholog_one2one ) Dog_ LZTS1 ( ortholog_one2one ) GuineaPig_ LZTS1 ( ortholog_one2one ) Macaque_ LZTS1 ( ortholog_one2one ) Mouse_ Lzts1 ( ortholog_one2one ) Pig_ LZTS1 ( ortholog_one2one ) Rat_ Lzts1 ( ortholog_one2one ) Rabbit_ LZTS1 ( ortholog_one2one ) |
| Ohnologs | LZTS3, LZTS2 |
| Paralogs | LZTS2, LZTS3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. {ECO:0000269|PubMed:10097140}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs28937897 rs34620053 rs119473032 rs723874 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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