| Gene Information | |
|---|---|
| Gene Name | SLPI |
| Organism | Homo sapiens (Human) |
| Gene Length | 132 |
| Protein Names | Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000124107 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P03973 |
| Gene Card | SLPI |
| Uniprot ID | P03973 |
| Pfam | PF00095 |
| In ASD | no |
| Allosteric Prediction | no (-0.511001554) |
| Ortholog in Animals | Alpaca_ SLPI ( ortholog_one2one ) Dog_ SLPI ( ortholog_one2one ) GuineaPig_ SLPI ( ortholog_one2one ) Macaque_ SLPI ( ortholog_one2one ) Mouse_ Slpi ( ortholog_one2one ) Pig_ SLPI ( ortholog_one2one ) Rat_ Slpil3 ( ortholog_one2many ) Rat_ Slpil2 ( ortholog_one2many ) Rat_ Slpi ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | WFDC3, WFDC12, WFDC10B, WFDC9, WFDC11, PI3, WFDC13, WFDC10A, WFDC5 |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (PubMed:24352879). Detected in bone marrow myeloid cells (PubMed:24352879). Detected in airway sputum (PubMed:2039600). Detected in parotid gland secretions (PubMed:3462719). Detected in seminal plasma (at protein level) (PubMed:3485543). Detected in uterus cervix (PubMed:3533531). {ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3485543, ECO:0000269|PubMed:3533531}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Z7F (X-ray 1.70A ) 4DOQ (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3485543}. |
| Mouse PG classification | NA |
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