Gene Information
Gene NameADCYAP1
OrganismHomo sapiens (Human)
Gene Length176
Protein NamesPituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)]
Target Namepituitary adenylate cyclase-activating 38
Target TypeClinical trial target
Gene Age645 ( ENSG00000141433 )
Evolutionary StageVertebrata
AlphaFoldDBP18509
Gene CardADCYAP1
Uniprot IDP18509
PfamPF00123
In ASDno
Allosteric Predictionyes (0.934786619)
Ortholog in AnimalsAlpaca_ ADCYAP1 ( ortholog_one2one )
Dog_ ADCYAP1 ( ortholog_one2one )
GuineaPig_ ADCYAP1 ( ortholog_one2one )
Macaque_ ADCYAP1 ( ortholog_one2one )
Mouse_ Adcyap1 ( ortholog_one2one )
Pig_ ADCYAP1 ( ortholog_one2one )
Rat_ Adcyap1 ( ortholog_one2one )
Rabbit_ ADCYAP1 ( ortholog_one2one )
OhnologsNA
ParalogsGHRH, VIP
Tissuebrain, pancreas
Tissue SpecificityNA
Pharmacological Animal Models0.077111(Chimpanzee);0.001000(Mouse);0.001823(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GEA  (NMR  -  )  2D2P  (NMR  -  )  2JOD  (NMR  -  )  6LPB  (EM  3.90A  )  6M1I  (EM  3.50A  )  6P9Y  (EM  3.01A  )  6VN7  (EM  3.20A  )  7VQX  (EM  2.74A  )  7WBJ  (EM  3.42A  ) 
DBSNP rs2856966 
Subcellular location [CC]Secreted.
Mouse PG classificationNA
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