| Gene Information | |
|---|---|
| Gene Name | HIPK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1198 |
| Protein Names | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) |
| Target Name | homeodomain-interacting protein kinase 2 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000064393 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H2X6 |
| Gene Card | HIPK2 |
| Uniprot ID | Q9H2X6 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.122159758) |
| Ortholog in Animals | Alpaca_ HIPK2 ( ortholog_one2one ) Dog_ HIPK2 ( ortholog_one2one ) GuineaPig_ HIPK2 ( ortholog_one2one ) Macaque_ HIPK2 ( ortholog_one2one ) Mouse_ Hipk2 ( ortholog_one2one ) Pig_ HIPK2 ( ortholog_one2one ) Rabbit_ HIPK2 ( ortholog_one2one ) |
| Ohnologs | HIPK3, HIPK1 |
| Paralogs | CLK1, HIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, DYRK3, CLK4, DYRK2, DYRK1A, CLK2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. {ECO:0000269|PubMed:11267674, ECO:0000269|PubMed:11798164}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047059(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6P5S (X-ray 2.19A ) 7NCF (X-ray 2.72A ) |
| DBSNP | rs56132157 rs35255718 |
| Subcellular location [CC] | Nucleus, PML body {ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:33591310}. Cytoplasm {ECO:0000269|PubMed:33591310}. Cytoplasm, Stress granule {ECO:0000269|PubMed:33591310}. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic. |
| Mouse PG classification | NA |
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