| Gene Information | |
|---|---|
| Gene Name | SLIT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1529 |
| Protein Names | Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145147 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94813 |
| Gene Card | SLIT2 |
| Uniprot ID | O94813 |
| Pfam | PF00008; PF12661; PF00054; PF13855; PF01463; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.299480285) |
| Ortholog in Animals | Alpaca_ SLIT2 ( ortholog_one2one ) Dog_ SLIT2 ( ortholog_one2one ) GuineaPig_ SLIT2 ( ortholog_one2one ) Macaque_ SLIT2 ( ortholog_one2one ) Mouse_ Slit2 ( ortholog_one2one ) Pig_ SLIT2 ( ortholog_one2one ) Rat_ Slit2 ( ortholog_one2one ) Rabbit_ SLIT2 ( ortholog_one2one ) |
| Ohnologs | SLIT3, SLIT1 |
| Paralogs | TLR9, LRRC70, LRFN2, LRFN5, SLITRK3, LRFN4, GP5, SLITRK2, LINGO1, TPBGL, SLITRK6, LRFN1, LRRN1, SLITRK1, LRTM2, SLIT3, LRRN2, LRRN3, LRRC38, SLITRK4, LINGO2, SLIT1, SLITRK5, LRRC55, LRFN3 |
| Tissue | NA |
| Tissue Specificity | Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined. {ECO:0000269|PubMed:10349621, ECO:0000269|PubMed:9813312}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2V70 (X-ray 3.01A ) 2V9S (X-ray 2.00A ) 2V9T (X-ray 1.70A ) 2WFH (X-ray 1.80A ) |
| DBSNP | rs771375896 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10102268}. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated. |
| Mouse PG classification | NA |
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