| Gene Information | |
|---|---|
| Gene Name | SOD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 240 |
| Protein Names | Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) |
| Target Name | superoxide dismutases |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000109610 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P08294 |
| Gene Card | SOD3 |
| Uniprot ID | P08294 |
| Pfam | PF00080 |
| In ASD | no |
| Allosteric Prediction | no (-0.10447522) |
| Ortholog in Animals | Alpaca_ SOD3 ( ortholog_one2one ) Dog_ SOD3 ( ortholog_one2one ) GuineaPig_ SOD3 ( ortholog_one2one ) Macaque_ SOD3 ( ortholog_one2one ) Mouse_ Sod3 ( ortholog_one2one ) Pig_ SOD3 ( ortholog_one2one ) Rat_ Sod3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SOD1, CCS |
| Tissue | NA |
| Tissue Specificity | Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JLP (X-ray 1.70A ) |
| DBSNP | rs2536512 rs17879876 rs1799895 |
| Subcellular location [CC] | Secreted, extracellular space. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. |
| Mouse PG classification | NA |
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