| Gene Information | |
|---|---|
| Gene Name | SENP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 644 |
| Protein Names | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000079387 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P0U3 |
| Gene Card | SENP1 |
| Uniprot ID | Q9P0U3 |
| Pfam | PF02902 |
| In ASD | no |
| Allosteric Prediction | yes (0.063298263) |
| Ortholog in Animals | Alpaca_ SENP1 ( ortholog_one2one ) Dog_ SENP1 ( ortholog_one2one ) GuineaPig_ SENP1 ( ortholog_one2one ) Macaque_ SENP1 ( ortholog_one2one ) Mouse_ Senp1 ( ortholog_one2one ) Pig_ SENP1 ( ortholog_one2one ) Rat_ Senp1 ( ortholog_one2one ) Rabbit_ SENP1 ( ortholog_one2one ) |
| Ohnologs | SENP2 |
| Paralogs | SENP5, SENP2, SENP3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269|PubMed:15487983}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2CKG (X-ray 2.45A ) 2CKH (X-ray 3.20A ) 2G4D (X-ray 2.80A ) 2IY0 (X-ray 2.77A ) 2IY1 (X-ray 2.46A ) 2IYC (X-ray 2.45A ) 2IYD (X-ray 3.20A ) 2XPH (X-ray 2.40A ) 2XRE (X-ray 2.45A ) 6NNQ (X-ray 2.62A ) |
| DBSNP | rs17854369 rs35130318 rs17854368 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25406032}. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. |
| Mouse PG classification | NA |
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