| Gene Information | |
|---|---|
| Gene Name | SLF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1173 |
| Protein Names | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000119906 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IX21 |
| Gene Card | SLF2 |
| Uniprot ID | Q8IX21 |
| Pfam | PF14816 |
| In ASD | no |
| Allosteric Prediction | no (-1.080088403) |
| Ortholog in Animals | Alpaca_ SLF2 ( ortholog_one2one ) Dog_ SLF2 ( ortholog_one2one ) GuineaPig_ SLF2 ( ortholog_one2one ) Macaque_ SLF2 ( ortholog_one2one ) Mouse_ Slf2 ( ortholog_one2one ) Pig_ SLF2 ( ortholog_one2one ) Rat_ Slf2 ( ortholog_one2one ) Rabbit_ SLF2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FAM178B |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:12459258). Expressed at higher level in skeletal muscle and at slightly lower level in brain, liver and heart, than in lung, kidney, spleen and thymus (PubMed:12459258). {ECO:0000269|PubMed:12459258}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10883563 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:25931565}. Note=Mainly localizes in the nucleus (PubMed:24561620). Colocalizes with PCNA on replication sites (PubMed:24561620). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:25931565}. |
| Mouse PG classification | NA |
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