| Gene Information | |
|---|---|
| Gene Name | SLF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1058 |
| Protein Names | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000133302 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9BQI6 |
| Gene Card | SLF1 |
| Uniprot ID | Q9BQI6 |
| Pfam | PF12796; PF16770 |
| In ASD | no |
| Allosteric Prediction | no (-1.081898627) |
| Ortholog in Animals | Alpaca_ SLF1 ( ortholog_one2one ) Dog_ SLF1 ( ortholog_one2one ) GuineaPig_ SLF1 ( ortholog_one2one ) Macaque_ SLF1 ( ortholog_one2one ) Mouse_ Slf1 ( ortholog_one2one ) Pig_ SLF1 ( ortholog_one2one ) Rabbit_ SLF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TOPBP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.075(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6891545 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25931565}. Cytoplasm {ECO:0000250|UniProtKB:Q8R3P9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R3P9}. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000250|UniProtKB:Q8R3P9, ECO:0000269|PubMed:25931565}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |