Gene Information
Gene NameSGSM2
OrganismHomo sapiens (Human)
Gene Length1006
Protein NamesSmall G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000141258 )
Evolutionary StageEumetazoa
AlphaFoldDBO43147
Gene CardSGSM2
Uniprot IDO43147
PfamPF12068; PF00566; PF02759
In ASDno
Allosteric Predictionno (-0.94410524)
Ortholog in AnimalsAlpaca_ SGSM2 ( ortholog_one2one )
Dog_ SGSM2 ( ortholog_one2one )
GuineaPig_ SGSM2 ( ortholog_one2one )
Macaque_ SGSM2 ( ortholog_one2one )
Mouse_ Sgsm2 ( ortholog_one2one )
Pig_ SGSM2 ( ortholog_one2one )
Rat_ Sgsm2 ( ortholog_one2one )
Rabbit_ SGSM2 ( ortholog_one2one )
OhnologsSGSM1
ParalogsTBC1D3C, TBC1D3D, TBC1D3, TBC1D3G, TBC1D3B, TBC1D3F, TBC1D3I, TBC1D3E, TBC1D3L, TBC1D3H, TBC1D3K, TBC1D8, TBC1D14, TBC1D10A, SGSM1, TBC1D8B, TBC1D2B, TBC1D10B, RABGAP1, TBC1D17, TBC1D9B, TBC1D25, TBC1D30, TBC1D26, TBC1D28, TBC1D22A, USP6NL, TBC1D9, RABGAP1L, TBC1D2, TBC1D13, TBC1D12, TBC1D4, GRTP1, EVI5, EVI5L, TBC1D15, SGSM3, TBC1D16, TBCK, TBC1D22B, TBC1D5, TBC1D1, TBC1D10C, TBC1D21
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:17509819}.
Pharmacological Animal Models0.117047(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs17853891  rs745400  rs17853888  rs17857178  rs2248821  rs17857180 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:26620560}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Melanosomal localization is mediated by RAB9A. {ECO:0000269|PubMed:26620560}.
Mouse PG classificationNA
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