| Gene Information | |
|---|---|
| Gene Name | TWF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000151239 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12792 |
| Gene Card | TWF1 |
| Uniprot ID | Q12792 |
| Pfam | PF00241 |
| In ASD | no |
| Allosteric Prediction | no (-0.300854444) |
| Ortholog in Animals | Alpaca_ TWF1 ( ortholog_one2one ) Dog_ TWF1 ( ortholog_one2one ) GuineaPig_ TWF1 ( ortholog_one2one ) Macaque_ TWF1 ( ortholog_one2one ) Mouse_ Twf1 ( ortholog_one2one ) Pig_ TWF1 ( ortholog_one2one ) Rat_ Twf1 ( ortholog_one2many ) Rat_ AC124205.1 ( ortholog_one2many ) Rabbit_ TWF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TWF2 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. {ECO:0000269|PubMed:7507208}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7CCC (X-ray 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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