| Gene Information | |
|---|---|
| Gene Name | SLCO1B3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 702 |
| Protein Names | Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) |
| Target Name | solute carrier organic anion transporter family member 1b3 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000111700 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPD5 |
| Gene Card | SLCO1B3 |
| Uniprot ID | Q9NPD5 |
| Pfam | PF07648; PF03137 |
| In ASD | no |
| Allosteric Prediction | yes (0.48057518) |
| Ortholog in Animals | Alpaca_ SLCO1B3 ( ortholog_one2one ) Dog_ SLCO1B3 ( ortholog_one2many ) Macaque_ SLCO1B3 ( ortholog_one2one ) Mouse_ Slco1b2 ( ortholog_one2many ) Rat_ Slco1b2 ( ortholog_one2many ) |
| Ohnologs | SLCO5A1 |
| Paralogs | SLCO5A1, SLCO6A1, SLCO4C1, SLCO4A1, SLCO1B1, SLCO1A2, SLCO1C1, SLCO2B1, SLCO2A1, SLCO3A1 |
| Tissue | liver |
| Tissue Specificity | Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein (PubMed:10779507). Expressed in liver (at protein level) (PubMed:15159445). Expressed in the placenta (PubMed:12409283). Not detected in other tissues (PubMed:10779507). {ECO:0000269|PubMed:10779507, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:15159445}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs4149117 rs7311358 rs60140950 rs12299012 rs556554798 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:10779507}; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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