| Gene Information | |
|---|---|
| Gene Name | SLC9A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 834 |
| Protein Names | Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) |
| Target Name | sodium/hydrogen exchanger 3 |
| Target Type | Successful target |
| Gene Age | 1292 ( ENSG00000066230 ) 3 ( ENSG00000281861 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48764 |
| Gene Card | SLC9A3 |
| Uniprot ID | P48764 |
| Pfam | PF00999 |
| In ASD | no |
| Allosteric Prediction | yes (0.510626655) |
| Ortholog in Animals | Alpaca_ SLC9A3 ( ortholog_one2one ) Dog_ SLC9A3 ( ortholog_one2one ) GuineaPig_ SLC9A3 ( ortholog_one2one ) Macaque_ SLC9A3 ( ortholog_one2one ) Mouse_ Slc9a3 ( ortholog_one2one ) Pig_ SLC9A3 ( ortholog_one2one ) Rat_ Slc9a3 ( ortholog_one2one ) Rabbit_ SLC9A3 ( ortholog_one2one ) |
| Ohnologs | SLC9A5 |
| Paralogs | SLC9A7, SLC9A6, SLC9C1, SLC9A4, SLC9A1, SLC9A9, SLC9A5, SLC9A2, SLC9A8, SLC9C2 |
| Tissue | small.intestine |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7X2U (EM 3.20A ) |
| DBSNP | rs1047334552 rs869312807 rs869312806 rs766076524 rs2247114 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:26358773}; Multi-pass membrane protein {ECO:0000269|PubMed:19088451}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). {ECO:0000250|UniProtKB:Q28362}. |
| Mouse PG classification | HPG |
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