| Gene Information | |
|---|---|
| Gene Name | FGFR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 822 |
| Protein Names | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) |
| Target Name | fibroblast growth factor receptor 1 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000077782 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P11362 |
| Gene Card | FGFR1 |
| Uniprot ID | P11362 |
| Pfam | PF07679; PF00047; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.162015803) |
| Ortholog in Animals | Alpaca_ FGFR1 ( ortholog_one2one ) Dog_ FGFR1 ( ortholog_one2one ) GuineaPig_ FGFR1 ( ortholog_one2one ) Macaque_ FGFR1 ( ortholog_one2one ) Mouse_ Fgfr1 ( ortholog_one2one ) Pig_ FGFR1 ( ortholog_one2one ) Rat_ Fgfr1 ( ortholog_one2many ) Rabbit_ FGFR1 ( ortholog_one2one ) |
| Ohnologs | FGFR2, FGFR3, FGFR4 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. {ECO:0000269|PubMed:1652059}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AGW (X-ray 2.40A ) 1CVS (X-ray 2.80A ) 1EVT (X-ray 2.80A ) 1FGI (X-ray 2.50A ) 1FGK (X-ray 2.00A ) 1FQ9 (X-ray 3.00A ) 1XR0 (NMR - ) 2CR3 (NMR - ) 2FGI (X-ray 2.50A ) 3C4F (X-ray 2.07A ) 3DPK (X-ray 1.95A ) 3GQI (X-ray 2.50A ) 3GQL (X-ray 2.80A ) 3JS2 (X-ray 2.20A ) 3KRJ (X-ray 2.10A ) 3KRL (X-ray 2.40A ) 3KXX (X-ray 3.20A ) 3KY2 (X-ray 2.70A ) 3OJV (X-ray 2.60A ) 3RHX (X-ray 2.01A ) 3TT0 (X-ray 2.80A ) 4F63 (X-ray 2.55A ) 4F64 (X-ray 2.05A ) 4F65 (X-ray 2.26A ) 4NK9 (X-ray 2.57A ) 4NKA (X-ray 2.19A ) 4NKS (X-ray 2.50A ) 4RWI (X-ray 2.29A ) 4RWJ (X-ray 2.49A ) 4RWK (X-ray 2.98A ) 4RWL (X-ray 2.19A ) 4UWB (X-ray 2.31A ) 4UWC (X-ray 1.96A ) 4UWY (X-ray 2.31A ) 4V01 (X-ray 2.33A ) 4V04 (X-ray 2.12A ) 4V05 (X-ray 2.57A ) 4WUN (X-ray 1.65A ) 4ZSA (X-ray 2.00A ) 5A46 (X-ray 2.63A ) 5A4C (X-ray 2.09A ) 5AM6 (X-ray 1.96A ) 5AM7 (X-ray 1.96A ) 5B7V (X-ray 2.15A ) 5EW8 (X-ray 1.63A ) 5FLF (X-ray 2.58A ) 5O49 (X-ray 1.91A ) 5O4A (X-ray 2.01A ) 5UQ0 (X-ray 2.30A ) 5UR1 (X-ray 2.20A ) 5VND (X-ray 2.20A ) 5W21 (X-ray 3.00A ) 5W59 (X-ray 2.50A ) 5Z0S (X-ray 2.45A ) 5ZV2 (X-ray 2.86A ) 6C18 (X-ray 2.30A ) 6C19 (X-ray 2.12A ) 6C1B (X-ray 2.00A ) 6C1C (X-ray 2.15A ) 6C1O (X-ray 2.29A ) 6ITJ (X-ray 1.99A ) 6MZQ (X-ray 2.00A ) 6MZW (X-ray 2.20A ) 6NVL (X-ray 2.70A ) 6P68 (X-ray 2.90A ) 6P69 (X-ray 2.20A ) 7OZB (X-ray 1.71A ) 7OZD (X-ray 1.82A ) 7OZF (X-ray 1.82A ) |
| DBSNP | rs760884357 rs17175750 rs121909640 rs140254426 rs767195580 rs1554570706 rs727505373 rs55642501 rs747842199 rs780765366 rs121913473 rs765615419 rs397515481 rs121909630 rs869025669 rs17851623 rs121909635 rs121909645 rs121909627 rs121913472 rs1131691929 rs727505369 rs121909633 rs121909632 rs121909638 rs886037634 rs121909641 rs121909631 rs121909634 rs121909637 rs397515444 rs869025670 rs749758370 rs779707422 rs121909629 rs121909628 rs398122946 rs869025671 rs869025672 rs869320694 rs1563433902 rs397515446 rs727505376 rs397515445 rs768957161 rs1085307879 rs267606805 rs121909642 rs267606806 rs398122945 rs121909644 rs2956723 rs56234888 rs781328162 rs17182456 rs17182463 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. |
| Mouse PG classification | HPG |
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