| Gene Information | |
|---|---|
| Gene Name | SLC6A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 630 |
| Protein Names | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) |
| Target Name | sodium-dependent serotonin transporter |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000108576 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P31645 |
| Gene Card | SLC6A4 |
| Uniprot ID | P31645 |
| Pfam | PF03491; PF00209 |
| In ASD | yes |
| Allosteric Prediction | yes (1.098947053) |
| Ortholog in Animals | Alpaca_ SLC6A4 ( ortholog_one2one ) Dog_ SLC6A4 ( ortholog_one2one ) GuineaPig_ SLC6A4 ( ortholog_one2one ) Macaque_ SLC6A4 ( ortholog_one2one ) Mouse_ Slc6a4 ( ortholog_one2one ) Pig_ SLC6A4 ( ortholog_one2one ) Rat_ Slc6a4 ( ortholog_one2one ) Rabbit_ SLC6A4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC6A20, SLC6A9, SLC6A2, SLC6A18, SLC6A7, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12, SLC6A3 |
| Tissue | lung, placenta, small.intestine |
| Tissue Specificity | Expressed in platelets (at protein level). {ECO:0000269|PubMed:17506858}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5I6X (X-ray 3.14A ) 5I6Z (X-ray 4.53A ) 5I71 (X-ray 3.15A ) 5I73 (X-ray 3.24A ) 5I74 (X-ray 3.40A ) 5I75 (X-ray 3.49A ) 6AWN (X-ray 3.62A ) 6AWO (X-ray 3.53A ) 6AWP (X-ray 3.80A ) 6AWQ (X-ray 4.05A ) 6DZV (EM 4.20A ) 6DZW (EM 4.30A ) 6DZY (EM 4.10A ) 6DZZ (EM 3.60A ) 6VRH (EM 3.30A ) 6VRK (EM 4.10A ) 6VRL (EM 3.80A ) 6W2B (X-ray 4.70A ) 6W2C (X-ray 6.30A ) 7LI6 (EM 3.50A ) 7LI7 (EM 4.10A ) 7LI8 (EM 3.90A ) 7LI9 (EM 3.90A ) 7LIA (EM 3.30A ) 7LWD (EM 3.65A ) 7MGW (EM 3.50A ) |
| DBSNP | rs6355 rs2228673 rs28914832 rs28914832 rs28914833 rs28914834 rs6352 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:27049939}; Multi-pass membrane protein {ECO:0000269|PubMed:27049939}. Endomembrane system {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:17506858}. |
| Mouse PG classification | NA |
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