| Gene Information | |
|---|---|
| Gene Name | SLC5A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 659 |
| Protein Names | Solute carrier family 5 member 4 |
| Target Name | sodium/glucose cotransporter 2 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000100191 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NY91 |
| Gene Card | SLC5A4 |
| Uniprot ID | Q9NY91 |
| Pfam | PF00474 |
| In ASD | no |
| Allosteric Prediction | yes (0.249236886) |
| Ortholog in Animals | Alpaca_ SLC5A4 ( ortholog_one2one ) Dog_ SLC5A4 ( ortholog_one2one ) GuineaPig_ SLC5A4 ( ortholog_one2one ) Macaque_ SLC5A4 ( ortholog_one2one ) Mouse_ Slc5a4a ( ortholog_one2one ) Pig_ SLC5A4 ( ortholog_one2one ) Rat_ Slc5a4 ( ortholog_one2one ) Rabbit_ SLC5A4 ( ortholog_one2one ) |
| Ohnologs | SLC5A2 |
| Paralogs | SLC5A11, SLC5A5, SLC5A8, SLC5A1, SLC5A6, SLC5A9, SLC5A3, SLC5A10, SLC5A2, SLC5A12, SLC5A7 |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068). {ECO:0000269|PubMed:13130073, ECO:0000269|PubMed:22766068}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16990065 rs2235171 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:13130073, ECO:0000305|PubMed:17110502, ECO:0000305|PubMed:20421923, ECO:0000305|PubMed:22766068}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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