| Gene Information | |
|---|---|
| Gene Name | SLC7A7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) |
| Target Name | y+l amino acid transporter 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000155465 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UM01 |
| Gene Card | SLC7A7 |
| Uniprot ID | Q9UM01 |
| Pfam | PF13520 |
| In ASD | no |
| Allosteric Prediction | no (-0.389933575) |
| Ortholog in Animals | Alpaca_ SLC7A7 ( ortholog_one2one ) GuineaPig_ SLC7A7 ( ortholog_one2one ) Macaque_ SLC7A7 ( ortholog_one2one ) Mouse_ Slc7a7 ( ortholog_one2one ) Pig_ SLC7A7 ( ortholog_one2one ) Rat_ Slc7a7 ( ortholog_one2one ) Rabbit_ SLC7A7 ( ortholog_one2one ) |
| Ohnologs | SLC7A6, SLC7A5, SLC7A10 |
| Paralogs | SLC7A6, SLC7A10, SLC7A9, SLC7A8, SLC7A11, SLC7A13, SLC7A14, SLC7A3, SLC7A2, SLC7A4, SLC7A1, SLC7A5 |
| Tissue | NA |
| Tissue Specificity | Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line. {ECO:0000269|PubMed:10080183, ECO:0000269|PubMed:11078698, ECO:0000269|PubMed:11742806, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs386833792 rs386833811 rs386833793 rs121908677 rs11568438 rs386833814 rs386833815 rs386833816 rs11568437 rs386833819 rs386833820 rs386833823 rs386833824 rs386833825 rs386833829 rs72552272 rs386833795 rs386833797 rs386833799 rs386833810 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:15756301}; Multi-pass membrane protein {ECO:0000269|PubMed:15756301}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |