| Gene Information | |
|---|---|
| Gene Name | STIL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1287 |
| Protein Names | SCL-interrupting locus protein (TAL-1-interrupting locus protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000123473 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15468 |
| Gene Card | STIL |
| Uniprot ID | Q15468 |
| Pfam | PF15253 |
| In ASD | no |
| Allosteric Prediction | no (-0.256462875) |
| Ortholog in Animals | Alpaca_ STIL ( ortholog_one2one ) Dog_ STIL ( ortholog_one2one ) GuineaPig_ STIL ( ortholog_one2one ) Macaque_ STIL ( ortholog_one2one ) Mouse_ Stil ( ortholog_one2one ) Pig_ STIL ( ortholog_one2one ) Rat_ Stil ( ortholog_one2one ) Rabbit_ STIL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. {ECO:0000269|PubMed:15107824, ECO:0000269|PubMed:1922059}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YYP (X-ray 2.60A ) 5LHW (X-ray 0.91A ) 5LHZ (X-ray 2.51A ) |
| DBSNP | rs3125630 rs398122976 rs13376679 rs3766317 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60988}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835}. |
| Mouse PG classification | HPG |
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