| Gene Information | |
|---|---|
| Gene Name | CYP2C8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) |
| Target Name | cytochrome p450 2c8 |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000138115 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P10632 |
| Gene Card | CYP2C8 |
| Uniprot ID | P10632 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.980872158) |
| Ortholog in Animals | Alpaca_ CYP2C8 ( ortholog_one2one ) Macaque_ CYP2C19 ( ortholog_one2many ) |
| Ohnologs | CYP2U1 |
| Paralogs | CYP2S1, CYP2W1, CYP2D6, CYP2C18, CYP2C9, CYP2C19, CYP2B6, CYP2U1, CYP2A6, CYP2A7, CYP2A13, CYP2F1, CYP2R1, CYP2E1, CYP2J2 |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PQ2 (X-ray 2.70A ) 2NNH (X-ray 2.60A ) 2NNI (X-ray 2.80A ) 2NNJ (X-ray 2.28A ) 2VN0 (X-ray 2.70A ) |
| DBSNP | rs11572080 rs142886225 rs72558195 rs188934928 rs11572102 rs769460274 rs1058930 rs11572103 rs72558194 rs10509681 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Mouse PG classification | NA |
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