| Gene Information | |
|---|---|
| Gene Name | SPG11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2443 |
| Protein Names | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000104133 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96JI7 |
| Gene Card | SPG11 |
| Uniprot ID | Q96JI7 |
| Pfam | PF14649 |
| In ASD | no |
| Allosteric Prediction | no (-0.934652454) |
| Ortholog in Animals | Alpaca_ SPG11 ( ortholog_one2one ) Dog_ SPG11 ( ortholog_one2one ) Macaque_ SPG11 ( ortholog_one2one ) Mouse_ Spg11 ( ortholog_one2one ) Pig_ SPG11 ( ortholog_one2one ) Rat_ Spg11 ( ortholog_one2one ) Rabbit_ SPG11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons. {ECO:0000269|PubMed:17322883, ECO:0000269|PubMed:24794856}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3759875 rs312262723 rs3759871 rs779830116 rs1555451521 rs1567149547 rs371334506 rs764647588 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:17322883}. Nucleus {ECO:0000269|PubMed:17322883}. Cell projection, axon {ECO:0000269|PubMed:24794856}. Cell projection, dendrite {ECO:0000269|PubMed:24794856}. Note=Mainly cytoplasmic. {ECO:0000269|PubMed:17322883}. |
| Mouse PG classification | HPG |
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