Gene Information
Gene NameSLC3A2
OrganismHomo sapiens (Human)
Gene Length630
Protein Names4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
Target Namelymphocyte activation antigen 4f2
Target TypeClinical trial target
Gene Age544 ( ENSG00000168003 )
Evolutionary StageEuk+Bac
AlphaFoldDBP08195
Gene CardSLC3A2
Uniprot IDP08195
PfamPF00128; PF16028
In ASDno
Allosteric Predictionyes (0.3841855)
Ortholog in AnimalsAlpaca_ SLC3A2 ( ortholog_one2one )
Dog_ SLC3A2 ( ortholog_one2one )
GuineaPig_ SLC3A2 ( ortholog_one2one )
Macaque_ SLC3A2 ( ortholog_one2one )
Mouse_ Slc3a2 ( ortholog_one2one )
Pig_ SLC3A2 ( ortholog_one2one )
Rat_ Slc3a2 ( ortholog_one2one )
Rabbit_ SLC3A2 ( ortholog_one2one )
OhnologsNA
ParalogsAMY2B, AMY1C, AMY1B, AMY1A, AMY2A, SLC3A1, GBE1
TissueNA
Tissue SpecificityExpressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001615(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DH2  (X-ray  2.10A  )  2DH3  (X-ray  2.80A  )  6IRS  (EM  3.30A  )  6IRT  (EM  3.50A  )  6JMQ  (EM  3.31A  )  6JMR  (EM  4.10A  )  6S8V  (X-ray  1.80A  )  7B00  (EM  3.98A  )  7CCS  (EM  6.20A  )  7P9U  (EM  3.70A  )  7P9V  (EM  3.40A  ) 
DBSNP NA 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:9829974};
Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269|PubMed:17081065}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058, PubMed:11311135). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.
Mouse PG classificationNA
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