| Gene Information | |
|---|---|
| Gene Name | SLC5A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 635 |
| Protein Names | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) |
| Target Name | sodium-dependent multivitamin transporter |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000138074 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y289 |
| Gene Card | SLC5A6 |
| Uniprot ID | Q9Y289 |
| Pfam | PF00474 |
| In ASD | no |
| Allosteric Prediction | no (-0.43137582) |
| Ortholog in Animals | Alpaca_ SLC5A6 ( ortholog_one2one ) Dog_ SLC5A6 ( ortholog_one2one ) Macaque_ SLC5A6 ( ortholog_one2one ) Mouse_ Slc5a6 ( ortholog_one2one ) Pig_ SLC5A6 ( ortholog_one2one ) Rat_ Slc5a6 ( ortholog_one2one ) Rabbit_ SLC5A6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC5A11, SLC5A5, SLC5A8, SLC5A1, SLC5A9, SLC5A3, SLC5A10, SLC5A4, SLC5A2, SLC5A12, SLC5A7 |
| Tissue | placenta |
| Tissue Specificity | Expressed in microvessels of the brain (at protein level) (PubMed:25809983). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:10329687). {ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:25809983}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs994218778 rs370950187 rs1395 rs1064845 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:27904971}; Multi-pass membrane protein {ECO:0000255}.; Cell membrane {ECO:0000269|PubMed:28052864}; Multi-pass membrane protein {ECO:0000255}. Note=(Microbial infection) Exposure to E.coli lipopolysaccharides leeds to reduced cell membrane localization. {ECO:0000269|PubMed:28052864}. |
| Mouse PG classification | NA |
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