| Gene Information | |
|---|---|
| Gene Name | KIF4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1232 |
| Protein Names | Chromosome-associated kinesin KIF4A (Chromokinesin-A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000090889 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95239 |
| Gene Card | KIF4A |
| Uniprot ID | O95239 |
| Pfam | PF00225 |
| In ASD | no |
| Allosteric Prediction | yes (0.020200187) |
| Ortholog in Animals | Alpaca_ KIF4A ( ortholog_one2one ) Dog_ KIF4A ( ortholog_one2one ) GuineaPig_ KIF4A ( ortholog_one2one ) Macaque_ KIF4A ( ortholog_one2one ) Mouse_ Kif4 ( ortholog_one2one ) Pig_ KIF4A ( ortholog_one2one ) Rat_ Kif4a ( ortholog_one2one ) Rabbit_ KIF4A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | NA |
| Tissue Specificity | Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. {ECO:0000269|PubMed:10978527}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6OYL (X-ray 3.15A ) |
| DBSNP | rs1199457 rs2297871 rs1046485 |
| Subcellular location [CC] | Nucleus matrix {ECO:0000269|PubMed:11736643}. Cytoplasm {ECO:0000269|PubMed:11736643}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Chromosome {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Note=Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105). Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660). In anaphase, associates with the mitotic spindle midzone (PubMed:15297875). In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:29848660, PubMed:15297875). Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). Does not localize to the nucleolus (PubMed:11736643). {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| Mouse PG classification | NA |
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