| Gene Information | |
|---|---|
| Gene Name | SLC38A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | Putative sodium-coupled neutral amino acid transporter 8 (Solute carrier family 38 member 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000166558 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | A6NNN8 |
| Gene Card | SLC38A8 |
| Uniprot ID | A6NNN8 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | no (-1.108912594) |
| Ortholog in Animals | Alpaca_ SLC38A8 ( ortholog_one2one ) Dog_ SLC38A8 ( ortholog_one2one ) GuineaPig_ SLC38A8 ( ortholog_one2one ) Macaque_ SLC38A8 ( ortholog_one2one ) Mouse_ Slc38a8 ( ortholog_one2one ) Pig_ SLC38A8 ( ortholog_one2one ) Rat_ Slc38a8 ( ortholog_one2one ) Rabbit_ SLC38A8 ( ortholog_one2one ) |
| Ohnologs | SLC38A7, SLC38A1, SLC38A2, SLC38A3 |
| Paralogs | SLC38A3, SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A2, SLC36A2, SLC38A4, SLC38A11, SLC38A6, SLC32A1, SLC38A1, SLC38A5 |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal and adult brain, and spinal cord. In the brain, it is localized in the cell body and axon of the majority of neuronal cells and in a subset of glial cells. Found throughout the neuronal retina, with higher expression levels in the inner and outer plexiform layers and the photoreceptor layer. Very weak expression is also present in the kidneys, thymus, and testes. {ECO:0000269|PubMed:24290379}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777253 rs11862366 rs372929441 rs587777254 rs587777256 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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