| Gene Information | |
|---|---|
| Gene Name | CFL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 166 |
| Protein Names | Cofilin-2 (Cofilin, muscle isoform) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000165410 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y281 |
| Gene Card | CFL2 |
| Uniprot ID | Q9Y281 |
| Pfam | PF00241 |
| In ASD | no |
| Allosteric Prediction | no (-1.000009811) |
| Ortholog in Animals | Alpaca_ CFL2 ( ortholog_one2one ) Dog_ CFL2 ( ortholog_one2one ) GuineaPig_ CFL2 ( ortholog_one2one ) Macaque_ CFL2 ( ortholog_one2one ) Mouse_ Cfl2 ( ortholog_one2one ) Pig_ CFL2 ( ortholog_one2one ) Rat_ Cfl2 ( ortholog_one2one ) Rabbit_ CFL2 ( ortholog_one2one ) |
| Ohnologs | DSTN, CFL1 |
| Paralogs | CFL1, DSTN |
| Tissue | NA |
| Tissue Specificity | Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001375(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7M0G (NMR - ) |
| DBSNP | rs397515451 rs80358250 |
| Subcellular location [CC] | Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with CSPR3 in the Z line of sarcomeres. {ECO:0000269|PubMed:19752190}. |
| Mouse PG classification | HPG |
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