| Gene Information | |
|---|---|
| Gene Name | SLC38A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) |
| Target Name | sodium-coupled neutral amino acid transporters |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000111371 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H2H9 |
| Gene Card | SLC38A1 |
| Uniprot ID | Q9H2H9 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | no (-0.208990929) |
| Ortholog in Animals | Alpaca_ SLC38A1 ( ortholog_one2one ) Dog_ SLC38A1 ( ortholog_one2one ) GuineaPig_ SLC38A1 ( ortholog_one2one ) Macaque_ SLC38A1 ( ortholog_one2one ) Mouse_ Slc38a1 ( ortholog_one2one ) Pig_ SLC38A1 ( ortholog_one2one ) Rat_ Slc38a1 ( ortholog_one2one ) Rabbit_ SLC38A1 ( ortholog_one2one ) |
| Ohnologs | SLC38A5, SLC38A8, SLC38A3 |
| Paralogs | SLC38A3, SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A8, SLC38A2, SLC36A2, SLC38A4, SLC38A11, SLC38A6, SLC32A1, SLC38A5 |
| Tissue | NA |
| Tissue Specificity | Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747). {ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:15054072, ECO:0000269|PubMed:16148032, ECO:0000269|PubMed:20599747}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}. |
| Mouse PG classification | NA |
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