| Gene Information | |
|---|---|
| Gene Name | SLC36A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1) |
| Target Name | solute carrier family 36 member 2 |
| Target Type | Literature-reported target |
| Gene Age | >4290 ( ENSG00000186335 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q495M3 |
| Gene Card | SLC36A2 |
| Uniprot ID | Q495M3 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | no (-0.278281927) |
| Ortholog in Animals | Alpaca_ SLC36A2 ( ortholog_one2one ) Dog_ SLC36A2 ( ortholog_one2one ) GuineaPig_ SLC36A2 ( ortholog_one2one ) Macaque_ SLC36A2 ( ortholog_one2one ) Mouse_ Slc36a2 ( ortholog_one2one ) Pig_ SLC36A2 ( ortholog_one2one ) Rat_ Slc36a2 ( ortholog_one2one ) Rabbit_ SLC36A2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC38A3, SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A8, SLC38A2, SLC38A4, SLC38A11, SLC38A6, SLC32A1, SLC38A1, SLC38A5 |
| Tissue | kidney, artery, skeletal.muscle, tibial.nerve |
| Tissue Specificity | Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule close to the glomerulus. {ECO:0000269|PubMed:15058382, ECO:0000269|PubMed:19033659}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs77010315 rs10042608 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19033659}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BHK3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8BHK3}. |
| Mouse PG classification | NA |
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