| Gene Information | |
|---|---|
| Gene Name | PDE10A |
| Organism | Homo sapiens (Human) |
| Gene Length | 779 |
| Protein Names | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000112541 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y233 |
| Gene Card | PDE10A |
| Uniprot ID | Q9Y233 |
| Pfam | PF01590; PF00233 |
| In ASD | yes |
| Allosteric Prediction | yes (1.335375974) |
| Ortholog in Animals | Alpaca_ PDE10A ( ortholog_one2one ) Dog_ PDE10A ( ortholog_one2one ) GuineaPig_ PDE10A ( ortholog_one2one ) Macaque_ PDE10A ( ortholog_one2one ) Mouse_ Pde10a ( ortholog_one2one ) Pig_ PDE10A ( ortholog_one2one ) Rat_ Pde10a ( ortholog_one2one ) Rabbit_ PDE10A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum. {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:27058447}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OUN (X-ray 1.56A ) 2OUP (X-ray 1.56A ) 2OUQ (X-ray 1.90A ) 2OUR (X-ray 1.45A ) 2OUS (X-ray 1.45A ) 2OUU (X-ray 1.52A ) 2OUV (X-ray 1.56A ) 2OUY (X-ray 1.90A ) 2WEY (X-ray 2.80A ) 2Y0J (X-ray 2.43A ) 2ZMF (X-ray 2.10A ) 3SN7 (X-ray 1.82A ) 3SNI (X-ray 1.90A ) 3SNL (X-ray 2.40A ) 3UI7 (X-ray 2.28A ) 3UUO (X-ray 2.11A ) 3WI2 (X-ray 2.26A ) 3WS8 (X-ray 2.60A ) 3WS9 (X-ray 2.99A ) 3WYK (X-ray 2.50A ) 3WYL (X-ray 2.68A ) 3WYM (X-ray 2.00A ) 4AEL (X-ray 2.20A ) 4AJD (X-ray 2.30A ) 4AJF (X-ray 1.90A ) 4AJG (X-ray 2.30A ) 4AJM (X-ray 2.40A ) 4BBX (X-ray 2.50A ) 4DDL (X-ray 2.07A ) 4DFF (X-ray 2.11A ) 4FCB (X-ray 2.10A ) 4FCD (X-ray 2.02A ) 4HEU (X-ray 2.00A ) 4HF4 (X-ray 2.00A ) 4LKQ (X-ray 1.62A ) 4LLJ (X-ray 1.56A ) 4LLK (X-ray 1.55A ) 4LLP (X-ray 1.75A ) 4LLX (X-ray 1.75A ) 4LM0 (X-ray 1.66A ) 4LM1 (X-ray 1.60A ) 4LM2 (X-ray 1.55A ) 4LM3 (X-ray 1.49A ) 4LM4 (X-ray 1.48A ) 4MRW (X-ray 1.96A ) 4MRZ (X-ray 1.58A ) 4MS0 (X-ray 1.79A ) 4MSA (X-ray 1.62A ) 4MSC (X-ray 2.47A ) 4MSE (X-ray 2.81A ) 4MSH (X-ray 2.30A ) 4MSN (X-ray 2.30A ) 4MUW (X-ray 2.64A ) 4MVH (X-ray 2.50A ) 4P0N (X-ray 2.08A ) 4P1R (X-ray 2.24A ) 4PHW (X-ray 2.50A ) 4TPM (X-ray 2.77A ) 4TPP (X-ray 2.65A ) 4WN1 (X-ray 3.13A ) 4XY2 (X-ray 2.03A ) 4YQH (X-ray 2.31A ) 4YS7 (X-ray 2.50A ) 4ZO5 (X-ray 2.50A ) 5AXP (X-ray 1.95A ) 5AXQ (X-ray 1.77A ) 5B4K (X-ray 2.90A ) 5B4L (X-ray 2.40A ) 5C1W (X-ray 1.70A ) 5C28 (X-ray 1.56A ) 5C29 (X-ray 2.05A ) 5C2A (X-ray 2.00A ) 5C2E (X-ray 2.10A ) 5C2H (X-ray 2.09A ) 5DH4 (X-ray 2.20A ) 5DH5 (X-ray 2.00A ) 5EDE (X-ray 2.20A ) 5EDG (X-ray 2.30A ) 5EDH (X-ray 2.03A ) 5EDI (X-ray 2.20A ) 5I2R (X-ray 2.50A ) 5K9R (X-ray 2.70A ) 5UWF (X-ray 1.87A ) 5XUI (X-ray 2.77A ) 5XUJ (X-ray 2.44A ) 5ZNL (X-ray 2.80A ) 6IJH (X-ray 2.60A ) 6IJI (X-ray 2.70A ) 6KDX (X-ray 2.44A ) 6KDZ (X-ray 3.10A ) 6KE0 (X-ray 2.95A ) 6KO0 (X-ray 2.60A ) 6KO1 (X-ray 2.70A ) 6KZE (X-ray 2.50A ) 6MSA (X-ray 2.06A ) 6MSC (X-ray 2.36A ) 7BPI (X-ray 2.40A ) |
| DBSNP | rs778899140 rs875989839 rs875989841 rs875989840 rs2224252 rs2860112 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10441464}. |
| Mouse PG classification | NA |
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