Gene Information
Gene NameSLC2A4
OrganismHomo sapiens (Human)
Gene Length509
Protein NamesSolute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Target Nameglucose transporter type 4
Target TypeClinical trial target
Gene Age454 ( ENSG00000181856 )
3 ( ENSG00000288174 )
Evolutionary StageEuk+Bac
AlphaFoldDBP14672
Gene CardSLC2A4
Uniprot IDP14672
PfamPF00083
In ASDno
Allosteric Predictionyes (1.418938078)
Ortholog in AnimalsAlpaca_ SLC2A4 ( ortholog_one2one )
Dog_ SLC2A4 ( ortholog_one2one )
GuineaPig_ SLC2A4 ( ortholog_one2one )
Macaque_ SLC2A4 ( ortholog_one2one )
Mouse_ Slc2a4 ( ortholog_one2one )
Pig_ SLC2A4 ( ortholog_one2one )
Rat_ Slc2a4 ( ortholog_one2one )
Rabbit_ SLC2A4 ( ortholog_one2one )
OhnologsSLC2A1, SLC2A2
ParalogsSLC2A8, SLC2A7, SLC2A6, SLC2A5, SLC2A11, SLC2A2, SLC2A1, SLC2A3, SLC2A14, SLC2A13, SLC2A9, SLC2A12, SLC2A10
Tissueadipose.tissue, heart, sigmoid.colon
Tissue SpecificitySkeletal and cardiac muscles;
brown and white fat.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7WSM  (EM  3.25A  )  7WSN  (EM  3.31A  ) 
DBSNP rs35198331  rs5434  rs8192702  rs121434581  rs775242206 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:P14142};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142}. Endomembrane system {ECO:0000269|PubMed:8300557};
Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P14142}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557). The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557). Insulin stimulation induces translocation to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P14142, ECO:0000269|PubMed:8300557}.
Mouse PG classificationNA
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