Gene Information
Gene NameTNFRSF10B
OrganismHomo sapiens (Human)
Gene Length440
Protein NamesTumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Target Nametumor necrosis factor receptor superfamily member 10b
Target TypeNA
Gene Age55 ( ENSG00000120889 )
Evolutionary StageVertebrata
AlphaFoldDBO14763
Gene CardTNFRSF10B
Uniprot IDO14763
PfamPF00531; PF00020
In ASDyes
Allosteric Predictionyes (1.014814403)
Ortholog in AnimalsAlpaca_ TNFRSF10B ( ortholog_one2one )
Macaque_ TNFRSF10B ( ortholog_one2one )
Mouse_ Tnfrsf26 ( ortholog_many2many )
Mouse_ Tnfrsf23 ( ortholog_many2many )
Mouse_ Tnfrsf22 ( ortholog_many2many )
Rat_ Tnfrsf22 ( ortholog_many2many )
Rat_ Tnfrsf26 ( ortholog_many2many )
OhnologsNA
ParalogsTNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B
TissueNA
Tissue SpecificityWidely expressed in adult and fetal tissues;
very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361;
highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract;
not detectable in brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1D0G  (X-ray  2.40A  )  1D4V  (X-ray  2.20A  )  1DU3  (X-ray  2.20A  )  1ZA3  (X-ray  3.35A  )  2H9G  (X-ray  2.32A  )  3X3F  (X-ray  2.10A  )  4I9X  (X-ray  2.10A  )  4N90  (X-ray  3.30A  )  4OD2  (X-ray  3.20A  )  6NHW  (NMR  -  )  6NHY  (NMR  -  )  6T3J  (X-ray  3.05A  ) 
DBSNP rs1129424  rs1047266  rs13265018 
Subcellular location [CC]Membrane;
Single-pass type I membrane protein.
Mouse PG classificationNA
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