| Gene Information | |
|---|---|
| Gene Name | SLC29A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 456 |
| Protein Names | Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) |
| Target Name | equilibrative nucleoside transporter 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000112759 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99808 |
| Gene Card | SLC29A1 |
| Uniprot ID | Q99808 |
| Pfam | PF01733 |
| In ASD | yes |
| Allosteric Prediction | yes (1.571242276) |
| Ortholog in Animals | Alpaca_ SLC29A1 ( ortholog_one2one ) Dog_ SLC29A1 ( ortholog_one2one ) GuineaPig_ SLC29A1 ( ortholog_one2one ) Mouse_ Slc29a1 ( ortholog_one2one ) Pig_ SLC29A1 ( ortholog_one2one ) Rat_ Slc29a1 ( ortholog_one2one ) Rabbit_ SLC29A1 ( ortholog_one2one ) |
| Ohnologs | SLC29A2 |
| Paralogs | SLC29A2, SLC29A3, SLC29A4 |
| Tissue | NA |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23219802}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6OB6 (X-ray 2.90A ) 6OB7 (X-ray 2.30A ) |
| DBSNP | rs45573936 rs45458701 rs767108156 |
| Subcellular location [CC] | Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. |
| Mouse PG classification | NA |
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