| Gene Information | |
|---|---|
| Gene Name | ARHGAP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1502 |
| Protein Names | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100852 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13017 |
| Gene Card | ARHGAP5 |
| Uniprot ID | Q13017 |
| Pfam | PF01846; PF00071; PF00620; PF16512; PF19518 |
| In ASD | no |
| Allosteric Prediction | yes (0.148569017) |
| Ortholog in Animals | Alpaca_ ARHGAP5 ( ortholog_one2one ) Dog_ ARHGAP5 ( ortholog_one2one ) GuineaPig_ ARHGAP5 ( ortholog_one2one ) Macaque_ ARHGAP5 ( ortholog_one2one ) Mouse_ Arhgap5 ( ortholog_one2one ) Pig_ ARHGAP5 ( ortholog_one2one ) Rat_ Arhgap5 ( ortholog_one2one ) Rabbit_ ARHGAP5 ( ortholog_one2one ) |
| Ohnologs | ARHGAP35 |
| Paralogs | TCERG1, TCERG1L |
| Tissue | NA |
| Tissue Specificity | Detected in skin fibroblasts (at protein level) (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EE4 (NMR - ) 2EE5 (NMR - ) 5U4V (X-ray 2.60A ) |
| DBSNP | rs17386818 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:8537347}. Cell membrane {ECO:0000269|PubMed:8537347}; Peripheral membrane protein {ECO:0000269|PubMed:8537347}. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269|PubMed:8537347}. |
| Mouse PG classification | NA |
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