| Gene Information | |
|---|---|
| Gene Name | SPHK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-) |
| Target Name | sphingosine kinase 1 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000176170 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NYA1 |
| Gene Card | SPHK1 |
| Uniprot ID | Q9NYA1 |
| Pfam | PF00781 |
| In ASD | yes |
| Allosteric Prediction | yes (1.125786976) |
| Ortholog in Animals | Alpaca_ SPHK1 ( ortholog_one2one ) Dog_ SPHK1 ( ortholog_one2one ) GuineaPig_ SPHK1 ( ortholog_one2one ) Macaque_ SPHK1 ( ortholog_one2one ) Mouse_ Sphk1 ( ortholog_one2one ) Pig_ SPHK1 ( ortholog_one2one ) Rat_ Sphk1 ( ortholog_one2one ) Rabbit_ SPHK1 ( ortholog_one2one ) |
| Ohnologs | SPHK2 |
| Paralogs | CERK, SPHK2, CERKL, AGK |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. Expressed in brain cortex (at protein level) (PubMed:29662056). {ECO:0000269|PubMed:10802064, ECO:0000269|PubMed:29662056}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3VZB (X-ray 2.00A ) 3VZC (X-ray 2.30A ) 3VZD (X-ray 2.30A ) 4L02 (X-ray 2.75A ) 4V24 (X-ray 1.80A ) |
| DBSNP | rs346803 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Nucleus {ECO:0000269|PubMed:14575709, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:29662056}. Cell membrane {ECO:0000269|PubMed:19854831}. Endosome membrane {ECO:0000269|PubMed:24929359}; Peripheral membrane protein {ECO:0000269|PubMed:24929359}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:24929359}. Synapse {ECO:0000250|UniProtKB:Q8CI15}. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity). {ECO:0000250|UniProtKB:Q8CI15, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:24929359}. |
| Mouse PG classification | NA |
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