| Gene Information | |
|---|---|
| Gene Name | SLC24A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 622 |
| Protein Names | Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000140090 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8NFF2 |
| Gene Card | SLC24A4 |
| Uniprot ID | Q8NFF2 |
| Pfam | PF01699 |
| In ASD | no |
| Allosteric Prediction | no (-0.619605907) |
| Ortholog in Animals | Dog_ SLC24A4 ( ortholog_one2one ) GuineaPig_ SLC24A4 ( ortholog_one2one ) Macaque_ SLC24A4 ( ortholog_one2one ) Mouse_ Slc24a4 ( ortholog_one2one ) Pig_ SLC24A4 ( ortholog_one2one ) Rat_ Slc24a4 ( ortholog_one2one ) Rabbit_ SLC24A4 ( ortholog_one2one ) |
| Ohnologs | SLC24A3 |
| Paralogs | SLC24A3, SLC24A1, SLC24A5, SLC24A2 |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in all regions of the brain, aorta, lung and thymus (PubMed:12379639). Expressed at lower levels in the stomach and intestine (PubMed:12379639). {ECO:0000269|PubMed:12379639}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777537 rs587777536 rs4900130 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8CGQ8}. |
| Mouse PG classification | HPG |
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