| Gene Information | |
|---|---|
| Gene Name | EDNRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) |
| Target Name | endothelin-1 receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000151617 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P25101 |
| Gene Card | EDNRA |
| Uniprot ID | P25101 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.619682697) |
| Ortholog in Animals | Alpaca_ EDNRA ( ortholog_one2one ) Dog_ EDNRA ( ortholog_one2one ) GuineaPig_ EDNRA ( ortholog_one2one ) Macaque_ EDNRA ( ortholog_one2one ) Mouse_ Ednra ( ortholog_one2one ) Pig_ EDNRA ( ortholog_one2one ) Rat_ Ednra ( ortholog_one2one ) Rabbit_ EDNRA ( ortholog_one2one ) |
| Ohnologs | EDNRB |
| Paralogs | EDNRB, BRS3, NMBR, GRPR, NTSR1, GHSR, NMUR2, NTSR2, GPR39, NMUR1, MLNR, GPR37, TRHR, GPR148, GPR37L1 |
| Tissue | NA |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269|PubMed:8611157, ECO:0000269|PubMed:9284755}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs786205230 rs876657388 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
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