| Gene Information | |
|---|---|
| Gene Name | CYP4F8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000186526 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P98187 |
| Gene Card | CYP4F8 |
| Uniprot ID | P98187 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.233591518) |
| Ortholog in Animals | Alpaca_ CYP4F8 ( ortholog_one2one ) GuineaPig_ CYP4F8 ( ortholog_one2one ) Mouse_ Cyp4f16 ( ortholog_one2many ) Mouse_ Cyp4f13 ( ortholog_one2many ) Mouse_ Cyp4f17 ( ortholog_one2many ) Mouse_ Cyp4f37 ( ortholog_one2many ) Rat_ Cyp4f5 ( ortholog_one2many ) Rat_ Cyp4f6 ( ortholog_one2many ) Rat_ Cyp4f37 ( ortholog_one2many ) |
| Ohnologs | CYP4B1, CYP4Z1, CYP4X1, CYP4A11 |
| Paralogs | CYP4F12, CYP4A22, CYP4A11, CYP4B1, CYP4F11, CYP19A1, CYP4F2, CYP4F22, CYP4X1, CYP4Z1, CYP4F3, CYP4V2 |
| Tissue | seminal.vesicle, vas.deferens |
| Tissue Specificity | Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions. {ECO:0000269|PubMed:10405341, ECO:0000269|PubMed:12464258, ECO:0000269|PubMed:15789615}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2072600 rs2056822 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}. Microsome membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}. |
| Mouse PG classification | NA |
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