| Gene Information | |
|---|---|
| Gene Name | SLC22A18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 424 |
| Protein Names | Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000110628 ) 3 ( ENSG00000276130 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96BI1 |
| Gene Card | SLC22A18 |
| Uniprot ID | Q96BI1 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | no (-0.701917754) |
| Ortholog in Animals | Alpaca_ SLC22A18 ( ortholog_one2one ) Dog_ SLC22A18 ( ortholog_one2one ) GuineaPig_ SLC22A18 ( ortholog_one2one ) Macaque_ SLC22A18 ( ortholog_one2one ) Mouse_ Slc22a18 ( ortholog_one2one ) Pig_ SLC22A18 ( ortholog_one2one ) Rat_ Slc22a18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung. {ECO:0000269|PubMed:9499412, ECO:0000269|PubMed:9520460, ECO:0000269|PubMed:9570947, ECO:0000269|PubMed:9744804}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1048046 rs1048047 rs121909071 rs141165353 rs1129782 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269|PubMed:9744804}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |