| Gene Information | |
|---|---|
| Gene Name | SLC21A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 691 |
| Protein Names | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y6L6 |
| Gene Card | SLCO1B1 |
| Uniprot ID | Q9Y6L6 |
| Pfam | PF07648; PF03137 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:12196548, PubMed:22232210). Expressed in liver (at protein level) (PubMed:15159445). Expressed in fetal liver (PubMed:10873595). Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte (PubMed:10358072, PubMed:10873595). {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:22232210}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs56101265 rs56061388 rs2306283 rs2306282 rs11045819 rs72559745 rs4149056 rs72559746 rs751709893 rs11045852 rs55901008 rs56387224 rs72559748 rs59502379 rs34671512 rs56199088 rs55737008 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Note=Detected in basolateral membranes of hepatocytes. |
| Mouse PG classification | NA |
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