| Gene Information | |
|---|---|
| Gene Name | SLC16A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) |
| Target Name | monocarboxylate transporter 3 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000100156 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95907 |
| Gene Card | SLC16A8 |
| Uniprot ID | O95907 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | no (-0.628714716) |
| Ortholog in Animals | Alpaca_ SLC16A8 ( ortholog_one2one ) Dog_ SLC16A8 ( ortholog_one2one ) GuineaPig_ SLC16A8 ( ortholog_one2one ) Macaque_ SLC16A8 ( ortholog_one2one ) Mouse_ Slc16a8 ( ortholog_one2one ) Pig_ SLC16A8 ( ortholog_one2one ) Rat_ Slc16a8 ( ortholog_one2one ) |
| Ohnologs | SLC16A2, SLC16A6, SLC16A10, SLC16A3, SLC16A14, SLC16A5, SLC16A13 |
| Paralogs | SLC16A11, SLC16A10, SLC16A5, SLC16A12, SLC16A7, SLC16A14, SLC16A2, SLC16A4, SLC16A6, SLC16A1, SLC16A9, SLC16A3, SLC16A13 |
| Tissue | NA |
| Tissue Specificity | Retinal pigment epithelium. {ECO:0000269|PubMed:10493836}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4289289 rs2076371 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217}. |
| Mouse PG classification | NA |
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