| Gene Information | |
|---|---|
| Gene Name | SLC16A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 500 |
| Protein Names | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) |
| Target Name | monocarboxylate transporter 1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000155380 ) 3 ( ENSG00000281917 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P53985 |
| Gene Card | SLC16A1 |
| Uniprot ID | P53985 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | yes (0.986092401) |
| Ortholog in Animals | Alpaca_ SLC16A1 ( ortholog_one2one ) Dog_ SLC16A1 ( ortholog_one2many ) GuineaPig_ SLC16A1 ( ortholog_one2one ) Macaque_ SLC16A1 ( ortholog_one2one ) Mouse_ Slc16a1 ( ortholog_one2one ) Rat_ Slc16a1 ( ortholog_one2one ) Rabbit_ SLC16A1 ( ortholog_one2one ) |
| Ohnologs | SLC16A6, SLC16A7, SLC16A2 |
| Paralogs | SLC16A11, SLC16A10, SLC16A5, SLC16A12, SLC16A7, SLC16A14, SLC16A2, SLC16A8, SLC16A4, SLC16A6, SLC16A9, SLC16A3, SLC16A13 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:15901598, PubMed:15505343, PubMed:12115955). Detected in heart and in blood lymphocytes and monocytes (at protein level) (PubMed:15505343). {ECO:0000269|PubMed:12115955, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:15901598}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6LYY (EM 3.60A ) 6LZ0 (EM 3.60A ) 7CKO (EM 2.95A ) 7CKR (EM 3.00A ) 7DA5 (EM 3.30A ) |
| DBSNP | rs11551867 rs80358222 rs606231302 rs72552271 rs1049434 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345, ECO:0000269|PubMed:25957687}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53987}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Apical cell membrane {ECO:0000269|PubMed:15901598}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53987}. Note=Expression at the cell surface requires the ancillary proteins BSG and EMB. Binds preferentially to BSG. {ECO:0000269|PubMed:10921872}. |
| Mouse PG classification | NA |
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