| Gene Information | |
|---|---|
| Gene Name | SLC12A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1099 |
| Protein Names | Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter) |
| Target Name | solute carrier family 12 member 1 |
| Target Type | Successful target |
| Gene Age | 1292 ( ENSG00000074803 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q13621 |
| Gene Card | SLC12A1 |
| Uniprot ID | Q13621 |
| Pfam | PF00324; PF08403; PF03522 |
| In ASD | no |
| Allosteric Prediction | yes (0.628896722) |
| Ortholog in Animals | Alpaca_ SLC12A1 ( ortholog_one2one ) Dog_ SLC12A1 ( ortholog_one2one ) GuineaPig_ SLC12A1 ( ortholog_one2one ) Macaque_ SLC12A1 ( ortholog_one2one ) Mouse_ Slc12a1 ( ortholog_one2one ) Pig_ SLC12A1 ( ortholog_one2one ) Rat_ Slc12a1 ( ortholog_one2one ) Rabbit_ SLC12A1 ( ortholog_one2one ) |
| Ohnologs | SLC12A2 |
| Paralogs | SLC12A2, SLC12A8, SLC12A7, SLC12A4, SLC12A3, SLC12A5, SLC12A6, SLC12A9 |
| Tissue | kidney, cortex.of.kidney |
| Tissue Specificity | Kidney; localizes to the thick ascending limbs (at protein level). {ECO:0000269|PubMed:29993276}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs137853158 rs137853157 rs1552311 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250|UniProtKB:P55014}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |