| Gene Information | |
|---|---|
| Gene Name | SLC12A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1150 |
| Protein Names | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) |
| Target Name | solute carrier family 12 member 6 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000140199 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9UHW9 |
| Gene Card | SLC12A6 |
| Uniprot ID | Q9UHW9 |
| Pfam | PF00324; PF03522 |
| In ASD | no |
| Allosteric Prediction | no (-0.21345391) |
| Ortholog in Animals | Alpaca_ SLC12A6 ( ortholog_one2one ) Dog_ SLC12A6 ( ortholog_one2one ) GuineaPig_ SLC12A6 ( ortholog_one2one ) Macaque_ SLC12A6 ( ortholog_one2one ) Mouse_ Slc12a6 ( ortholog_one2one ) Pig_ SLC12A6 ( ortholog_one2one ) Rat_ Slc12a6 ( ortholog_one2one ) Rabbit_ SLC12A6 ( ortholog_one2one ) |
| Ohnologs | SLC12A5, SLC12A7 |
| Paralogs | SLC12A2, SLC12A8, SLC12A7, SLC12A1, SLC12A4, SLC12A3, SLC12A5, SLC12A9 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas (PubMed:10600773). Detected in umbilical vein endothelial cells (PubMed:16048901). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:16048901}.; [Isoform 2]: More abundant in kidney. {ECO:0000269|PubMed:16048901}.; [Isoform 5]: Testis specific. {ECO:0000269|PubMed:16048901}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6M1Y (EM 3.20A ) 6M22 (EM 2.70A ) 6Y5R (EM 3.76A ) 6Y5V (EM 4.08A ) 7AIN (EM 3.20A ) 7AIO (EM 3.31A ) 7D90 (EM 3.60A ) 7NGB (EM 3.64A ) |
| DBSNP | rs2705339 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000250|UniProtKB:Q924N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q924N4}. |
| Mouse PG classification | NA |
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